Rheumatoid arthritis (RA) is an autoimmune disease with polarization disorder toward Th1 and Th2 that produces proinflammatory cytokines such as IL-1β, IL-6, IL-17, TNF-α, IFN-γ and IL-8 and, as a result, causes an inflammatory state in the body.52-54 Patients with RA have very low levels of cytokines secreted by Th2 lymphocytes.52 All of these events lead to involvement and destruction of the joints. This evidence concerns the gene IL1B and rheumatoid arthritis.