Consistent with the literature, our observation shows that there was an increase in the TP53 gene expression, proliferation and proliferation-related signaling kinases in CRC cells.TP53 produces these responses largely by altering the expression of the LATS1 and STK3 gene sequences known to be under the transcriptional control of the TP53 gene and reflecting mutational inactivation. This evidence concerns the gene STK3 and colorectal carcinoma.