Serine/threonine kinase-3 (STK3) and LATS1 gene are important factors related to signal transduction in the SWH pathway.28 Adenovirus-mediated overexpression of LATS1 gene in HeLa and LATS1-/- cells causes suppression of tumor formation through induction of apoptosis.29 LATS1 is considered to exert a suppressive role in some tumors. The gene discussed is LATS1; the disease is neoplasm.