A high-efficiency strategy has been adopted in recent studies in order to activate mutations or to activate kinases in the initiation and progression of cancer by identifying misregulated expression in gene profiling experiments.34 Activated MST2 p53 protein is stabilized by the LATS-1 gene and downregulation of MST2 gene expression is often seen in human CRCs.29 Our findings found that the expression of STK3 gene in HT29 CRC cell lines decreased significantly in applications of 12.5 nM and 25 nM of apigenin after 24 hours and in applications of 25 nM and 50 nM of apigenin after 48 hours. This evidence concerns the gene TP53 and cancer.