Reporting that, the upregulation of TLR4 expression level increases ERK and AMPK activity.106 Another study showed that dihydroquercetin reduced inflammation in LPS-induced endotoxemia through enhancement of AMPK phosphorylation and downregulation of TLR4 expression.75 Another link of AMPK and TLR4 were documented in hypothalamic pharmacological activation of AMPK (hyp-AMPK) in LPS-treated mice. This evidence concerns the gene TLR4 and serum lipopolysaccharide activity.