PRKAA1 and ischemia: On the other side, there is a critical role of AMPK activation in glucose uptake and ATP production, especially in the energy deprivation status of ischemia, through translocation of the glucose transporter 4 from intracellular compartments the cell surface.103 Furthermore, apoptotic procedure induced by ischemia and infarction increased in AMPK-deleted mice,104,105 expressing the importance of AMPK as a double-edged sword.