The anti-inflammatory effects of AMPK activators have been shown to confer benefits in colitis,6,68 hepatitis and liver disturbances,69,70 autoimmune encephalomyelitis,71 osteoarthritis,72 endotoxemia,73-75 MI,76 angiogenesis,77 acute kidney injuries,78 and mouse lung injury model.79 The gene discussed is PRKAA1; the disease is serum lipopolysaccharide activity.