They indicated that AMPK can modulate the cardiac hypertrophy procedure,96 potentiate preconditioning effect in the ischemic heart,97 involves in the pathogenesis of the Wolf-Parkinson-White syndrome in case of mutations in the γ2 subunit of AMPK,98 plays as a prominent constitute in angiogenesis and neointimal hyperplasia and also unclarified traces of this enzyme was observed in atherosclerosis development.99 The gene discussed is PRKAA1; the disease is cardiac hypertrophy.