PIK3CA and cancer: High-frequency somatic mutations in OCCC include AT-rich interaction domain 1A (ARID1A) and phosphatidylinositol-4,5-bisphosphate3-kinase (PIK3) catalytic subunit alpha (PIK3CA), that is similar in endometriosis without cancer, while the common mutation in HGSOC and ECCC is tumor protein 53 (TP53) (Anglesio et al., 2017; Baniak et al., 2019; Wiegand et al., 2010).