PIK3CA and AIDS dementia complex: Several studies have used high-throughput genotyping platforms to address the integrated genomic and molecular characterization of SCC and ADC, shedding light into genes mutation more frequently present in SCC, such as PIK3CA, and others, such as KRAS mutations, that are almost uniquely restricted to ADC patients (Ojesina et al., 2014; Wright et al., 2013).