Calorie restriction or intermittent fasting (IF) may seem like an oxymoron in a cancer patient, but when implemented correctly, IF can cause a decrease in IGF-1 and insulin levels, which enhances cancer cells' sensitization to chemotherapy, such as NAC, while also promoting hematopoietic stem cell-based regeneration and reversing immunosuppressive action [85]. Here, IGF1 is linked to cancer.