BBS1 and Meckel syndrome: Comparison of the model trained on BBS1 genes to models trained on known disease gene sets (Supplementary Table S2) shows that BBS1 model is highly similar to Meckel syndrome (both 8 and 1), which is a disease closely related to BBS1 (Forsythe and Beales, 2013; Karmous-Benailly et al., 2005).