TMEM119+/MHC-II+ EVs were significantly increased in plasma samples 28 days post-stroke (6184 eV/μL ± 510.6) in comparison to baseline samples (3730 eV/μL ± 602 p = 0.0156) and saline injected rats (Fig. 5C, D). The gene discussed is TMEM119; the disease is stroke disorder.