CCL18 and acid sphingomyelinase deficiency: CCL18 has previously been shown to be elevated in serum/plasma from individuals with lysosomal diseases, specifically Gaucher disease [82], Niemann-Pick disease type B or acid sphingomyelinase deficiency [83], GM1 gangliosidosis [84], NPC [40] and possibly lysosomal acid lipase deficiency [85].