In addition, the effect of HERC2 on stemness-related gene expression (Fig. 6F and Supplementary Fig. S7A), sphere formation ability (Fig. 6G and Supplementary Fig. S7B), and sorafenib resistance (Fig. 6H and Supplementary Fig. S7C) were abolished in PTP1B knockout HCC cells. Here, HERC2 is linked to hepatocellular carcinoma.