HECT and RLD domain-containing E3 ubiquitin-protein ligase 2 (HERC2) belongs to the large HERC family of ubiquitin E3 ligases with multiple structural domains that have been implicated in a wide range of physiological processes, including membrane trafficking, immune response, DNA repair, inflammation, cell stress response, and cancer biology [16–18]. This evidence concerns the gene HERC2 and cancer.