HERC2 and hepatocellular carcinoma: Furthermore, migration assays showed decreased cell counts of HERC2 knockout Huh7 and Hep3B HCC cells in the lower chamber compared to their counterparts, while more migrated cells were found in the lower chamber than in the control groups when HERC2 levels were overexpressed in SMMC-7721 and HCC-97 h cells (Fig. 2G).