HERC2-deficient HCC cells promoted CD8+ T cells, CD4+ T cells, and CD56+ NK cells to produce IFN-γ, while HERC2-overexpressed HCC cells limited IFN-γ secretion from CD8+ T cells, CD4+ T cells, and CD56+ NK cells (Fig. 4C and Supplementary Fig. S2B and S2C). Here, CD4 is linked to hepatocellular carcinoma.