ABCA1 and cardiovascular disorder: ATP-binding cassette subfamily A member 1 (ABCA1) was selected in the HM populations when southern East Asians were used as a reference (rs2472377, rs2472508, rs10991415, rs4149310, rs4149311, rs2487052, XPEHH score > 1.5, and rs62566032, iHS score = 2.6302), and ABCA1 prevents cardiovascular disease by promoting the efflux of intracellular cholesterol and phospholipids, controlling the rate-limiting step of reverse cholesterol transport and by inhibiting inflammation and maintaining lipid homeostasis.