Low-density lipoprotein receptor (LDLR) was selected when using the population from southern East Asia as a reference (rs2738456\rs2738458\rs2569538\rs2569537\rs14158\rs143309, XPEHH score > 2); LDLR was selected in the HM populations when using the northern East Asian population as a reference (rs1433099, rs14158, rs2569537, rs5929, XPEHH score > 2), and LDLR achieves modulation of atherosclerosis by regulating cholesterol homeostasis (Li et al. 2021; Go and Mani 2012). The gene discussed is VLDLR; the disease is atherosclerosis.