Based on the RT-PCR and Western blot results in HCC, PDAC, lung cancer, and breast cancer, we found that LH1 was highly expressed in PLC/PRF/5 (HCC) and SW1990 (PDAC) cells, and its expression was low in SK-Hep1 (HCC), SNU449 (HCC), and PANC1 (PDAC) cells (Supplementary Fig. 2A and B). Here, PLOD1 is linked to hepatocellular carcinoma.