However, we found that LH1 overexpression could significantly promote the HCC (Fig. 2A) or PANC1 cells to pass through the 8 μm pores in the transwell migration assay (Fig. 2A and B), while knockdown of LH1 inhibited the migration of PLC/PRF/5 cells (Supplementary Fig. 4A). The gene discussed is HSPG2; the disease is hepatocellular carcinoma.