Consistent with alterations of GMB composition observed in AD patients, differences in the GMB have also been observed in AD mouse models, including 5XFAD [18, 19], APPSwe/PSEN1dE9 (APP/PS1) [20–23], and APPSwe/PSEN1L166P (APPPS1-21) [14] models compared with wildtype mice (Table 2). The gene discussed is APP; the disease is Alzheimer disease.