Although CUB shows promising anticancer-activity in multiple cancers types via inducing apoptosis, our knowledge of its underlying molecular mechanisms is very limited, e.g. regulating the tumour necrosis factor α (TNFα) and nuclear fractor-κB (NF-κB) expression, affecting the anti-inflammatory response [28], and activating the MAPK signaling pathway to promote apoptosis [13]. This evidence concerns the gene TNF and cancer.