After adjusting for potential confounders (including age, sex, education years, diabetes mellitus, baseline NIHSS score, and Hs-CRP levels), multivariable logistic regression analysis demonstrated that advanced liver fibrosis was independently associated with a higher risk of PSD (OR, 1.88; 95% CI, 1.03–3.42, P = 0.040). This evidence concerns the gene CRP and Hepatic fibrosis.