AKT1 and neoplasm: Interestingly, another recent publication further highlighted the importance of mTORC1 in relation to TPI function, where it was shown that TPI promotes tumor growth and migration through an association with cell division cycle associated 5 (CDCA5) which led to the activation of phosphatidylinositol-3-kinase (PI3K) and subsequent activation of the protein kinase B (Akt/PKB) and mTORC1 pathways (Jin et al. 2022).