LHFPL2 and cancer: While the functions of the esterase SIAE and the transmembrane protein LHFPL2 are unclear, increased expression of each is a marker for poor cancer prognostic: higher expression of SIAE is linked to poorer prognosis for patients with multiple myeloma and higher expression of LHFPL2 is linked to poorer prognosis for patients with liver cancer37,38.