PADI4 and Venous thrombosis: Mice deficient in NET formation (Pad4-/-) are protected from venous thrombosis in the IVC stenosis model of DVT35 and NETs can drive endothelial activation/death34, yet rats treated with a neutrophil-depleting antibody peri-IVC ligation develop larger thrombi and more adverse vein wall remodeling36,37.