Taking advantage of perspective data collection of the DiAKIdney (T1DM and AKI) cohort6 we aimed to evaluate (i) the prevalence and association of ESS with severity indexes of T1DM onset such as DKA and kidney damage (AKI, ATN, RTD), (ii) the relationship between clinical/metabolic parameters at T1DM onset and thyroid hormones, and (iii) the role of ESS as a prognostic indicator of delayed recovery from kidney damage. Here, TG is linked to type 1 diabetes mellitus.