Statistically significant decreases in disease free survival are evident in individuals where malignancies have elevated expression of CREB1, KDM7A, and forkhead box O-3 (FOXO3), and a decrease in overall survival with higher expression of TNF receptor associated factor 4 (TRAF4) and CASP9, suggesting that these genes may have a role in BlCa tumorigenesis (Supplementary Fig. 5). Here, CREB1 is linked to bladder transitional cell carcinoma.