Univariate analyses indicated that patients in the appropriate correction group were more likely to have community-onset (61% vs. 42%); symptoms (81% vs. 60%); low Charlson Comorbidity Index (CCI) scores (1 vs. 2 points); low initial serum [Na] concentrations (117 vs. 118 mEq/L); high serum albumin concentrations (3.6 vs. 3.3 g/dL); used thiazide diuretics (20% vs. 6%); syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (46% vs. 29%); and a drug-induced cause of hyponatremia (20% vs. 1%). The gene discussed is ALB; the disease is Down syndrome.