APOE and Anxiety: The directions of the component loadings in Factor 4 were such that decreasing plasma apoE levels and liver weight increased the activity levels in the open field, decreased anxiety levels in the open field, increased swim speeds during visible platform training, increased activity levels prior to the first tone during fear learning in the fear conditioning test, increased spontaneous alternation in the Y maze, and increased time spent in the novel arm in the 24 h Y maze.