Distance moved on the second day of open field testing, measures of anxiety in the open field, object recognition, swim speeds during visible platform training in the water maze, distance moved prior to the first tone during fear learning in the fear conditioning test, spontaneous alternation in the Y maze, percent time spent in the novel arm of the 24 h Y maze, plasma apoE levels and liver weight loaded on factor 4. The gene discussed is APOE; the disease is Anxiety.