Also, plasma apoE levels and liver weights, activity levels on the first day of the open field, anxiety measures on the second day of the open field, swim speeds and ability to locate the hidden platform in the water maze, time to locate the platform location in the probe trial, activity and spontaneous alternation in the Y maze, and percent entries in the novel arm of the 24 h Y maze loaded on factor 5. The gene discussed is APOE; the disease is Anxiety.