IFNA1 and adrenal cortex carcinoma: REACTOME analysis shows a similarity of enriched pathways in high-risk ACC, confirming a dysregulation of cell cycle and IFN signaling, and an increase in SUMOylation, a key post-translational modification associated with chromatin remodeling which play stress-mitigation function under strong oncogenic stimuli (FDR < 0.05, Fig. 1C,D, Supplementary Table S2).