By comparing the expression profile of ACC patients to cells, we found that the transcriptional profile of ACC (h-TERT) resembles that of ACC recurrent patients and indirectly links to myc expressing (Supplementary Fig. S1), suggesting that this molecular profile is maintained also when cancer cells are cultured in vitro, and collectively indicating ACC (h-TERT) as a cell model of aggressive ACC. The gene discussed is MYC; the disease is cancer.