In addition, several energy metabolic processes, such as the PI3K-Akt pathway (EPHA2, FLT4, ITGA5, and LPAR6), cholesterol metabolism (APOE and CD36), and insulin resistance (FOLR1, CALM14, and PPP1R3A), were enriched in ApoE4 mice (Fig. 1i). This evidence concerns the gene LPAR6 and Insulin resistance.