EPHA2 and Insulin resistance: In addition, several energy metabolic processes, such as the PI3K-Akt pathway (EPHA2, FLT4, ITGA5, and LPAR6), cholesterol metabolism (APOE and CD36), and insulin resistance (FOLR1, CALM14, and PPP1R3A), were enriched in ApoE4 mice (Fig. 1i).