Compared with vehicle-treated control mice, ATB1021-treated mice had reduced levels of the proinflammatory cytokines/chemokines Cxcl5, Il18, Cxcl9, Cxcl10, Il1b, and Il6 (Fig. 3e) and Ccl2 (Supplementary Fig. 3c) in the lung tissues after challenge with poly(I:C)-induced ALI. Here, IL18 is linked to acute respiratory distress syndrome.