In the presence of epidermal growth factor (EGF), the active Ras-superfamily mGTPases Arf1 on Golgi membrane recruit GIV/Girdin (a protein that is known to fuel aggressive traits in diverse cancers), and the latter works as guanine nucleotide exchange factor (GEF) to turn tGTPases Gi\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha \beta \gamma$$\end{document}αβγ on41–45. Here, CCDC88A is linked to cancer.