Besides, we found along with the tumor cell growth pattern, the elevated expression of proteins that regulating cell proliferation process, especially, MKI67 was significantly inhibited by the Palbociclib in PDC_CDKN2A/Bdel, whereas showed no significantly difference between PDCs_WT and PDCs_WT treated Palbociclib (Supplementary Fig. 11M, N, Supplementary Data 7). This evidence concerns the gene CDKN2A and neoplasm.