Importantly, patients with TP53 single mutant exhibited highest value of clinical detected tumor proliferative index (evaluated by Ki67 percentage of positive nuclei), and highest MKI67 protein expression comparing to patients with IDH1:TP53 co-mutations, suggested fast tumor cell proliferation might associate with the diverse prognosis between patients that harbored TP53 single mutant and IDH1:TP53 co-mutations (Supplementary Fig. 4D). The gene discussed is IDH1; the disease is neoplasm.