EGFR and neoplasm: Further correlation analysis revealed among the proteins that significantly elevated in EGFR mutation-plus-amplification group, ERK5 was the top ranked protein that showed both significant association with patients’ overall survivals (HR, 1.898; 95% CI, 1.314–2.741; p = 0.001) and positively correlated with the expression of cell proliferation marker Ki67 (Spearman’s r = 0.45, p < 0.01) (Fig. 3J), suggesting the strong association among increased expression of ERK5, tumor cell proliferation and EGFR genomic alterations (EGFR mutations and EGFR amplifications).