Along with our observation in tumor tissues, we found proteins that enriched in MAPK signaling pathway (ERK5, MAP2K5, MAP2K1, etc.), cell cycle process (MCM2/3/4, MKI67, etc.)and nucleotide metabolic process (TKT, PRPSAP1/2, PRPS1/2, etc.)were significantly elevated in PDCs_EGFRamp & mut, comparing to PDCs_WT. Here, PRPSAP1 is linked to neoplasm.