CDK4 and neoplasm: These findings confirmed the impacts of CDKN2A/B homozygous deletion in promoting tumor cell proliferation through increasing the CDK4/6 expression, and further illustrate the fundamental role of CDKN2A/B homozygous deletion in shaping the distinguished proteomic features of WHO_Grade4_Astrocytomas_IDH1mut comparing to WHO_Grade2_ and WHO_Grade3_Astrocytomas_IDH1mut.