Finally, intraperitoneal injection of ERK5-specific inhibitor XMD8-92 at a dose of 50 mg/kg per day delayed the xenograft growth of ERK5-overexpression tumor cells (Fig. 3Q, R), and these results further suggested that the kinase activity or some other unknown functions of ERK5 were important for glioma cell proliferation. The gene discussed is MAPK7; the disease is central nervous system cancer.