As a result, 19 kinases were activated in GBM samples, and CDK2 showed the most divergent kinase activity between GBM and LGG samples (Wilcoxon test, p < 0.05), indicating its potential association with the distinctive features of GBMs (Fig. 2G, Supplementary Fig. 5C, D). This evidence concerns the gene CDK2 and glioblastoma.