As we expected, although the protein expression of PRPS1, and PRPS2 were not associated with patients’ prognosis, the elevated phosphorylation of PRPS1/T225, and PRPS2/S41 were all negatively associated with patients’ overall survival (Fig. 4S, Supplementary Fig. 7L, M), supporting our hypothesis that ERK5 might promote tumor cell growth and led to poor prognosis through phosphorylating PRPS1/2. Here, MAPK7 is linked to neoplasm.