Our findings that REGO inhibits the expression of PI3K and its downstream regulator p-AKT (Fig. 3A, B) and SC79 not only restores REGO-induced proliferation and migration of cancer cells but also inhibits REGO-induced apoptosis (Fig. 3E–G) demonstrate that AKT plays an important role in REGO-induced apoptosis. The gene discussed is AKT1; the disease is cancer.