MAPT and Alzheimer disease: Alzheimer’s disease (AD) is thought to develop when abnormal amounts of amyloid beta (A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β) build up in the brain, either extracellularly as amyloid plaques, tau proteins or intracellularly as neurofibrillary tangles, affecting neuronal function, connectivity and leading to progressive brain function loss [9].