Since memory performances of VGLUT3–/– mice were comparable to controls when the water temperature was dropped to 19°C, we hypothesized that the improved memory performance of VGLUT3–/– mice could be related to their anxiety trait (Amilhon et al., 2010) as well as to their hypothalamic-pituitary-adrenal axis dysfunctions (Balázsfi et al., 2018) in less-stressful watermaze conditions (i.e., at 22°C). Here, SLC17A8 is linked to Anxiety.