Since VGLUT3–/– mice are more vulnerable to anxiety than WT mice (Amilhon et al., 2010), we explored the contribution of anxiety to memory formation and learning in VGLUT3–/– mice in a more stressful condition, when the water temperature was lowered to 19°C (Sandi et al., 1997). This evidence concerns the gene SLC17A8 and Anxiety.