This cross-analysis also revealed that the BTBD3 gene is potentially targeted by miR-181a-5p (He et al, 2015), the two of which were up-regulated in XLID affected individuals’ blood-derived LCLs (Fig 3A and C and Table 4), implicating a possible connection between them that differs from the canonical miRNA silencing pathway. The gene discussed is BTBD3; the disease is cask-related x-linked intellectual disability.