Interestingly, unlike our observed sensitization of iTAP/Frmd8 KO mice to DSS-triggered colitis (Figs 3 and S5), it has been shown that iRhom2 KO mice are not sensitized to DSS-induced colitis (Siggs et al, 2012; Geesala et al, 2019). This evidence concerns the gene FRMD8 and colitis.