These observations are potentially consistent with ADAM17-associated defects in the tumor microenvironment in the cleavage of pro-inflammatory factors (e.g., TNF, IL-6R) (Schumacher & Rose-John, 2022) that can recruit inflammatory cells to drive tumor cell proliferation, or the release of growth factors such as amphiregulin (Fig 5E and F) to promote tumor cell growth. This evidence concerns the gene IL6R and neoplasm.