RHBDF2 and infection: iRhom2 KOs develop normally but fail to secrete TNF, a key ADAM17 substrate that coordinates the responses to infection and chronic inflammatory diseases; loss of iRhom2 attenuates the development of multiple inflammatory diseases in mouse models (Adrain et al, 2012; McIlwain et al, 2012; Siggs et al, 2012; Issuree et al, 2013; Luo et al, 2016; Barnette et al, 2018; Chaohui et al, 2018; Qing et al, 2018; Sundaram et al, 2019; Adrain & Cavadas, 2020; Kim et al, 2020).