FRMD8 and neoplasm: As ADAM17 overexpression is associated with a higher risk of metastasis and a poorer prognosis in several types of cancer (McGowan et al, 2008; Jiao et al, 2018; Ni et al, 2020), we next determined the cell-autonomous impact of iTAP/Frmd8 upon tumor emergence in the lungs after the intravenous injection into WT mice of iTAP/Frmd8 KO LLC cells versus their appropriate parental control line (Fig 6A–E).