ADAM17 and neoplasm: As ADAM17 maturation is decreased in multiple tissues of iTAP/Frmd8 KO mice, including the lung (Oikonomidi et al, 2018), and defects in its sheddase activity were observed in ex vivo (Figs 1C–F and 3A) and in in vivo (Fig 3C) experiments, we next evaluated the effect of iTAP/Frmd8 depletion on tumor growth and metastasis.