AREG and neoplasm: These observations are potentially consistent with ADAM17-associated defects in the tumor microenvironment in the cleavage of pro-inflammatory factors (e.g., TNF, IL-6R) (Schumacher & Rose-John, 2022) that can recruit inflammatory cells to drive tumor cell proliferation, or the release of growth factors such as amphiregulin (Fig 5E and F) to promote tumor cell growth.