Consistent with this notion, ADAM17ex/ex mice are more profoundly sensitized to DSS-induced colitis (Chalaris et al, 2010) than appears to be the case in iTAP/Frmd8 KO mice (Fig 3), suggesting that the titer of mature ADAM17 available may be higher in iTAP/Frmd8 KO mice than in ADAM17ex/ex mice. Here, ADAM17 is linked to colitis.