Furthermore, we constructed a kinase activity-deficient STK24 mutant (STK24 K53R) (19, 20) and proved that the kinase activity of STK24 was required for its effects on invasion, migration, and proliferation of cancer cells (Fig. S2, A–D) Overall, the results of the current study demonstrated that cancer cells with higher STK24 expression have a higher proliferation, migration, and invasion potential. The gene discussed is STK24; the disease is cancer.