Oral administration of GTB inhibits MPTP-induced activation of p21Rasand NF-κB in the nigra of hemiparkinsonian monkeys. After establishing the neuroprotective dose of GTB in mice, we carried out our experiments in MPTP-induced hemiparkinsonian monkey, which closely mimic the pathological features of PD. Here, NFKB1 is linked to Parkinson disease.