GPT and cholestasis: A total of 27 studies [2, 13, 21–26, 28–39, 41, 42, 44–48] reported the effect of UDCA on ALT and the meta-analysis results showed that UDCA could decrease the serum level of ALT in children with cholestasis [MD = -13.89 U/L, 95%CI (-17.76, -10.02), P<0.000001; Low quality of evidence] (Fig 2).