For example, the deletion of the NADPH oxidase subunits p47phox and Nox-1 has been shown to have a blood pressure lowering effect and to prevent endothelial dysfunction in the model of angiotensin-II-induced hypertension in mice (Landmesser et al, 2002; Matsuno et al, 2005). Here, NCF1 is linked to endothelial dysfunction.