Accordingly, in the setting of nitrate tolerance (Kurz et al, 1999) and noise stress (Daiber et al, 2019a; Munzel et al, 2021), inhibitors of the RAAS were able to improve nitrate tolerance, to reduce vascular oxidative stress, to normalize blood pressure, and to improve endothelial dysfunction most likely due to a recoupling of the eNOS enzyme. The gene discussed is NOS3; the disease is endothelial dysfunction.