FMO5 and hypertensive disorder: Prominent examples for this cross talk between mitochondrial and NADPH oxidase-derived ROS were reported for GTN-induced nitrate tolerance (Wenzel et al, 2008) and angiotensin-II-induced hypertension (Dikalova et al, 2010a; Doughan et al, 2008; Kroller-Schon et al, 2014).