NOS3 and endothelial dysfunction: In most instances, it is likely that an uncoupled eNOS contributes to endothelial dysfunction since the subsequent studies in animals were able to identify the uncoupling process in full detail, for example, as shown for nitrate tolerance (Knorr et al, 2011; Munzel et al, 2000a) and noise exposure (Daiber et al, 2020a; Kroller-Schon et al, 2018; Munzel et al, 2017a).