However, we were able to obtain some evidence that anti–LAG-3+anti–PD-1 treatment can affect the phenotype of tumor-targeting T cell clones, as our supervised analysis with predicted anti-MART1AAGIGILTV clones showed that during treatment, the phenotype of these cells changed from LAG3+ effector cells to cells with increased IFNG expression. The gene discussed is PDCD1; the disease is neoplasm.