WWTR1 and cancer: Given the relatively higher proportion of MCCN tumors in the NElo NMF group 1, we speculate that YAP1 or WWTR1 expression could contribute to the poor prognosis for patients with MCCN, especially in light of the previously documented roles of YAP1 and WWTR1 in recurrence and drug resistance in other cancers (51, 52).