We next performed pseudotime trajectory analysis and confirmed a temporal “early” upregulation of KCNQ2/-3/-5 transcripts and a “late” downregulation, the latter corresponding to chronic stages of inflammation within a MS lesion (Figure 2, I–L, Supplemental Figure 3, E–G, and Supplemental Tables 8 and 9). This evidence concerns the gene KCNQ2 and myeloid sarcoma.