This point of view is reflected by several other authors [11, 15, 33, 41] and substantiated here for elderly, supposedly more fragile GBM, IDH-wildtype patients, since the overwhelming influence of maximized EOR has been shown to be of prognostic relevance in multiple prior studies on GBM in more age-balanced cohorts [34–36]. The gene discussed is IDH1; the disease is glioblastoma.