KIR3DL1 and AIDS: The aKIR allele at the KIR3DL1/S1 locus, KIR3DS1, in the presence of its Bw4-80I ligand, is associated with low setpoint HIV-1 viral load, slower progression to AIDS and low CD4+ T cell count and reduced occurrence of opportunistic infections in different HIV-1 infected cohorts (Barbour et al. 2007; Boelen et al. 2018; Martin et al. 2002; Pelak et al. 2011; Qi et al. 2006).