We found that the depletion of MIB2 in B16-F10 cells caused significant tumor regression and prolonged survival in immunocompetent C57BL/6 syngeneic mice but not in immunodeficient NOD/SCID IL2rgnull (NSG) mice (Figure 2, E–H, and Supplemental Figure 2C). Here, MIB2 is linked to neoplasm.