Importantly, SLE patient–derived monocytes expressed lower levels of NLRP12, but higher levels of RUNX1 protein than in healthy monocytes (Figure 3I, compiled data), and the elevated RUNX1 protein level was able to enhance the binding of RUNX1 protein to the NLRP12 promoter. This evidence concerns the gene NLRP12 and systemic lupus erythematosus.