Higher levels of the HDAC1-NLRP12 promoter association in SLE patient–derived PBMCs was observed (Figure 4F), implying that the recruitment of an epigenetic factor to the NLRP12 promoter caused NLRP12 transcriptional suppression in SLE patient–derived PBMCs. This evidence concerns the gene HDAC1 and systemic lupus erythematosus.