The genes that regulate the apoptotic pathway have been reported to be associated with SLE, in which FAS, TNFRS10B, CASP8, and CASP10 expression levels were all increased in IFN-α–treated and SLE monocytes, while the levels of the other measured genes were not identical between the IFN-α and SLE groups. The gene discussed is CASP8; the disease is systemic lupus erythematosus.