To confirm the effect of serum IFN-α in reducing NLRP12 expression, THP-1 cells were treated with sera from another 12 SLE patients in whom the IFN-α levels were undetectable (Supplemental Table 2), and those sera were unable to reduce NLRP12 expression (Figure 1P). Here, IFNA2 is linked to systemic lupus erythematosus.