NLRP12 expression in THP-1 cells treated with a half-dose of patient-derived sera was slightly higher than that in cells treated with the original concentration (Figure 1O), suggesting that the dose effect of serum IFN-α levels might be involved in determining NLRP12 expression in SLE patients (IFN-α level >20 pg/ml). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.