TBK1 and systemic lupus erythematosus: As expected, the basal levels (0 hours) of TBK1 and p65 were higher in patient-derived monocytes than in healthy monocytes, and poly(dA:dT) further induced higher levels of pTBK1 and p-p65 in SLE patient–derived monocytes than in healthy monocytes (Figure 5E).