In contrast, nonalcoholic steatohepatitis (NASH) studies have revealed that neutrophils undergo NETosis through the interaction of sphingosine-1-phosphate (S1P), a bioactive signaling lipid, with its extracellular cognitive G protein–coupled receptor ligands (S1PR1–5), four of which (S1PR1–4) associate with neutrophil activation (12, 13). The gene discussed is S1PR1; the disease is metabolic dysfunction-associated steatohepatitis.