MI-2 also induced robust apoptosis in MCL cells regardless of their IBN sensitivity (P < 0.001) (Supplemental Figure 3E), which was accompanied by cleavage of poly(ADP-ribose) polymerase (PARP) and caspase 3 in JeKo BTK KD-2 and primary MCL patient cells (Figure 3D). The gene discussed is CASP3; the disease is mantle cell lymphoma.