Transient knockdown (KD) of MALT1 expression by MALT1 shRNA (30) resulted in significant cell proliferation perturbation in vitro in all MCL cell lines tested at 24 (P < 0.05), 48 (P < 0.05), and 72 (P < 0.001) hours (Figure 2, D–F, and Supplemental Figure 2, B–D). The gene discussed is MALT1; the disease is mantle cell lymphoma.