Another approach could be the administration of small molecules that modulate epigenetic factors, such as inhibitors of histone deacetylases and BET/bromodomain proteins, which are well tolerated in vivo and have been shown to ameliorate various cardiac pathologies (e.g., hypertrophy and fibrosis) (17) but have never been tested in arrhythmias. The gene discussed is DNER; the disease is Arrhythmia.