KEAP1 and gastric cancer: To study the effect of the ETGE motif of FAM117B on regulation of KEAP1/NRF2 signaling in gastric cancer cells, HA-tagged FAM117B WT and ETGE mutants were expressed in HGC-27 and AGS cells, and then the protein levels of NRF2 and the mRNA levels of its downstream target genes were detected by Western blot and qPCR assays.