Higher expressed SMC4 related to the poorer prognosis of sarcoma (OS: HR = 1.92, P = 0.0049; RFS: HR = 2.09, P = 0.0029), breast cancer (OS: HR = 1.36, P = 0.0052; RFS: HR = 1.53, P = 1.7e-14; DMFS: HR = 1.38, P = 0.001), liver cancer (OS: HR = 1.95, P = 0.00012; RFS: HR = 1.64, P = 0.01; PPS: HR = 1.72, P = 0.00033; DSS: HR = 2.53, P = 2.8e-05) and ovarian cancer (OS: HR = 1.36, P = 0.0052; RFS: HR = 1.53, P = 1.7e-14; PFS: HR=1.31, P = 0.00029). The gene discussed is SMC4; the disease is breast carcinoma.