SMC4 was highly expressed in tumor samples including bladder cancer, kidney cancer, brain and CNS cancer, head and neck cancer, liver cancer, breast cancer, cervical cancer, colorectal cancer, gastric cancer, myeloma, lung cancer, lymphoma, ovarian cancer and sarcoma compared to normal tissue samples (Figure 1A and Supplementary Table 1). This evidence concerns the gene SMC4 and urinary bladder carcinoma.