Moreover, SIRT2 plasma levels were negatively correlated with medial orbitofrontal volumetry (Spearman rho = −0.5357; P value = 0.0422) (Fig. 4M), indicating that early treatment is crucial for limiting the progressive neurological dysfunction in HIV infection and suggesting that SIRT2 could serve as plasma biomarker for these degenerative processes. This evidence concerns the gene SIRT2 and HIV infectious disease.