In particular, read numbers for methylglyoxal synthase (EC 4.2.3.3; encoded by mgsA) and phosphate acetyltransferase (EC 2.3.1.8; encoded by pta) were significantly decreased in PJS patients (P = 0.0056 and P = 0.0017, respectively) and further decreased in patients with intussusception (P = 0.0405 and P = 0.0085, respectively [Fig. 6G and H]). The gene discussed is TPI1; the disease is Peutz-Jeghers syndrome.